ATP8B1-mediated spatial organization of Cdc42 signaling maintains singularity during enterocyte polarization
نویسندگان
چکیده
منابع مشابه
ATP8B1-mediated spatial organization of Cdc42 signaling maintains singularity during enterocyte polarization
During yeast cell polarization localization of the small GTPase, cell division control protein 42 homologue (Cdc42) is clustered to ensure the formation of a single bud. Here we show that the disease-associated flippase ATPase class I type 8b member 1 (ATP8B1) enables Cdc42 clustering during enterocyte polarization. Loss of this regulation results in increased apical membrane size with scattere...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2015
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.201505118